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KCNA5 / Kv1.5

potassium voltage-gated channel, shaker-related subfamily, member 5

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).

Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Family/Subfamily: Ion Channel , Potassium channel - Kv1 Shaker
Synonyms: KCNA5, Cardiac potassium channel, HCK1, HPCN1, HuK6, HuKVI, RMK2, PCN1, RK3, ATFB7, KV1.5, Potassium channel 1
Target Sequences: NM_002234 NP_002225.2 P22460

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KCNA5 / Kv1.5 (2)
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KCNA5 / Kv1.5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67 kDa
20 µg/$215
KCNA5 / Kv1.5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
67 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).