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KCNA4 / Kv1.4

potassium voltage-gated channel, shaker-related subfamily, member 4

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.

Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Family/Subfamily: Ion Channel , Potassium channel - Kv1 Shaker
Synonyms: KCNA4, Cardiac potassium channel, HBK4, HPCN2, HUKII, KV1.4, KCNA4L, RK8, Type A potassium channel, PCN2, RHK1, RK4, KCNA8, Potassium channel 2, RCK4
Target Sequences: NM_002233 NP_002224.1 P22459

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
KCNA4 / Kv1.4 (3)
No (3)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
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HEK 293 Cells
Myc-DDK (Flag)
73.7 kDa
100 µg/$710
KCNA4 / Kv1.4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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293T Cells
Myc-DDK (Flag)
73.7 kDa
20 µg/$215
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).