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KCNA2 / Kv1.2

potassium voltage-gated channel, shaker-related subfamily, member 2

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Family/Subfamily: Ion Channel , Potassium channel - Kv1 Shaker
Synonyms: KCNA2, HBK5, KV1.2, HuK4, MK2, NGK1, RBK2, HK4, HUKIV
Target Sequences: NM_004974 NP_004965.1 P16389

Publications (2)

1
Specific antibodies to the external vestibule of voltage-gated potassium channels block current. Zhou BY, Ma W, Huang XY. The Journal of general physiology. 1998 111:555-63. [PubMed:9524138] [PMC:PMC2217123]
2
Postsynaptic density-95 scaffolding of Shaker-type K channels in smooth muscle cells regulates the diameter of cerebral arteries. Joseph BK, Thakali KM, Pathan AR, Kang E, Rusch NJ, Rhee SW. The Journal of physiology. 2011 589:5143-52. [PubMed:21911612] [PMC:PMC3225670]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).