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KATNB1

katanin p80 (WD repeat containing) subunit B 1

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Gene Name: katanin p80 (WD repeat containing) subunit B 1
Synonyms: KATNB1, KAT, Katanin p80 subunit B1, Katanin (80 kDa), p80 katanin
Target Sequences: NM_005886 NP_005877.2 Q9BVA0

Publications (1)

1
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics. Jin M, Pomp O, Shinoda T, Toba S, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B, Hirotsune S. Scientific reports. 2017 7:39902. (WB; Human) [Full Text Article] [PubMed:28079116] [PMC:PMC5228124] Related Antibodies: LS-C173437.

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
KATNB1 (4)
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GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
KATNB1 Protein - Purified recombinant protein KATNB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
72.2 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
72.2 kDa
20 µg/$150
KATNB1 Protein - 12.5% SDS-PAGE of human KATNB1 stained with Coomassie Blue
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Wheat Germ Extract
GST
97.79 kDa
10 µg/$479; 25 µg/$670
KATNB1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
72.2 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).