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Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH2 is necessary for proper intracellular Ca2+ signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.
Gene Name: | junctophilin 2 |
Synonyms: | JPH2, JP-2, JP2, Junctophilin 2, CMH17, Junctophilin type 2, Junctophilin-2 |
Target Sequences: | NM_020433 NP_065166.2 Q9BR39 |
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