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JUN / c-Jun
c-Jun is a component of the transcription factor activator protein 1 (AP-1) that binds to and activates transcription at TRE/AP-1 elements. Phosphorylation of c-Jun at Ser 63/73, resulting in activation and c-Jun dependent transcription, occurs in response to extra or intracellular signals, including UV irradiation, growth factors and transforming oncoproteins.
, not assigned-Transcription factor
JUN, Activator protein 1, AP-1, C-Jun, Jun proto-oncogene, p39, Jun oncogene, Proto-oncogene c-Jun, AP1, Enhancer-binding protein AP1, G0s7, Transcription factor AP-1, v-jun
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Liao G, Tao Q, Kofron M, Chen JS, Schloemer A, Davis RJ, Hsieh JC, Wylie C, Heasman J, Kuan CY. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:16313-8. (WB)
Clara cells protein, prolactin and transcription factors of protein NF-?B and c-Jun/AP-1 levels in rats inhaled to stainless steel welding dust and its soluble form. Halatek T, Stanislawska M, Swiercz R, Domeradzka-Gajda K, Kuras R, Wasowicz W. International Journal of Occupational Medicine and Environmental Health. 2018 October;31:613-632. [Full Text Article]
HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy. Michael F Emmons, Fernanda Faião-Flores, Ritin Sharma, Ram Thapa, Jane L Messina, Jurgen C Becker, Dirk Schadendorf, Edward Seto, Vernon K Sondak, John M Koomen, Yian A Chen, Eric K Lau, Lixin Wan, Jonathan D Licht, Keiran S M Smalley. Cancer research. 2019 June;79:2947-2961. [Full Text Article]