JMY

junction mediating and regulatory protein, p53 cofactor

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

JMY (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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JMY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G129149

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.3 kDa

Price:

100 µg/$710

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Human JMY Protein (Recombinant GST, N-terminus) (aa535-634) - LS-G63654

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human JMY Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73027

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.3 kDa

Price:

20 µg/$1,107

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Human JMY Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G94228

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

111.3 kDa

Price:

20 µg/$215

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