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JMJD6 / PSR

jumonji domain containing 6

Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

Gene Name: jumonji domain containing 6
Synonyms: JMJD6, Jumonji domain containing 6, Lysyl-hydroxylase JMJD6, Phosphatidylserine receptor, KIAA0585, Protein PTDSR, PSR, PTDSR1, PTDSR
Target Sequences: AB011157 BAA25511.1 Q6NYC1

Publications (1)

1
Jmjd6a regulates GSK3ß RNA splicing in Xenopus laevis eye development. Shin JY, Son J, Kim WS, Gwak J, Ju BG. PloS one. 2019 July;14:e0219800. [Full Text Article] [PubMed:31361752] [PMC:PMC6667200]

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JMJD6 / PSR (65)
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JMJD6 / PSR Antibody - Anti-JMJD6 / PSR antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa214-263) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
JMJD6 / PSR Antibody - Anti-JMJD6 / PSR antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa214-263) (HRP) Antibody
Xenopus, Zebrafish, Bat, Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
JMJD6 / PSR Antibody - Anti-JMJD6 / PSR antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa214-263) (Biotin) Antibody
Xenopus, Zebrafish, Bat, Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
JMJD6 / PSR Antibody - Anti-JMJD6 / PSR antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa214-263) (FITC) Antibody
Xenopus, Zebrafish, Bat, Human, Chimpanzee, Orangutan
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
JMJD6 / PSR Antibody - Immunohistochemistry of JMJD6 in rat brain tissue with JMJD6 antibody at 2.5 µg/mL.
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
JMJD6 / PSR Antibody - Western blot of JMJD6 / PSR antibody.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-334) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
JMJD6 / PSR Antibody - Immunocytochemistry of HeLa cells using anti- JMJD6(N-terminus) antibody diluted 1:200.
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JMJD6 / PSR Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$356; 100 µl/$461
JMJD6 / PSR Antibody - Immunohistochemical analysis of JMJD6 staining in mouse brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ChrIP, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
JMJD6 / PSR Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
JMJD6 / PSR Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-320) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
JMJD6 / PSR Antibody - IHC of paraffin-embedded Cal27 Xenograft using PSR antibody at 1:100 dilution.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-234) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
JMJD6 / PSR Antibody - Immunohistochemistry of paraffin-embedded Human brain using JMJD6 Polyclonal Antibody at dilution of 1:40.
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
JMJD6 / PSR Antibody - Immunofluorescence (IF) analysis of HeLa cells using PSR Monoclonal Antibody.
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JMJD6 / PSR Mouse anti-Human Monoclonal Antibody
Mouse, Dog, Bovine, Rat, Human
IF, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
JMJD6 / PSR Antibody - Immunocytochemistry of HeLa cells using anti-JMJD6(N-terminus) mouse monoclonal antibody diluted 1:200.
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JMJD6 / PSR Mouse anti-Human Monoclonal Antibody
Human
ICC, WB
Unconjugated
100 µl/$391
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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JMJD6 / PSR Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
JMJD6 / PSR Antibody - JMJD6 Antibody - WB analysis of JMJD6 in A431 cell lysate.
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa150-350) Antibody
Human
ICC, WB
Unconjugated
50 µl/$386
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa284-311) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
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JMJD6 / PSR Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
JMJD6 / PSR Antibody - Western blot analysis of Human breast infiltrative duct tissue, using JMJD6 Polyclonal Antibody at dilution of 1:425.
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JMJD6 / PSR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Viewing 1-25 of 65 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).