JHDM1A / KDM2A

lysine (K)-specific demethylase 2A

JHDM1A / KDM2A is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.

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Proteins (1)

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Recombinant (1)

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JHDM1A / KDM2A (1)

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GST, N-terminus (1)

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Human (1)

Source

Wheat Germ Extract (1)

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Human JHDM1A / KDM2A Protein (Recombinant GST, N-terminus) (aa742-840) - LS-G64588

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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