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JHDM1A / KDM2A
lysine (K)-specific demethylase 2A
JHDM1A / KDM2A is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants.
| Gene Name: | lysine (K)-specific demethylase 2A |
| Synonyms: | KDM2A, CXXC8, FBL11, DKFZP434M1735, JHDM1A, F-box protein Fbl7, F-box/LRR-repeat protein 11, KIAA1004, FBXL11, Lysine-specific demethylase 2A, LILINA, SF-KDM2A, F-box protein Lilina, FBL7 |
| Target Sequences: | NM_012308 NP_036440.1 Q9Y2K7 |
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