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JCHAIN / Ig J Chain

immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Name:	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
Synonyms:	JCHAIN, IGCJ, Immunoglobulin J chain, IGJ, IgJ chain, JCH
Target Sequences:	M12759 AAA58902.1 P01591

Publications (2)

Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus. Tadaki Suzuki, Akira Kawaguchi, Akira Ainai, Shin-ichi Tamura, Ryo Ito, Pretty Multihartina, Vivi Setiawaty, Krisna Nur Andriana Pangesti, Takato Odagiri, Masato Tashiro, Hideki Hasegawa. Proceedings of the National Academy of Sciences of the United States of America. 2015 June;112:7809-14. [Full Text Article] [PubMed:26056267] [PMC:PMC4485102] Related Antibodies: LS-C666347.

Human Fc Receptor-like 3 Inhibits Regulatory T Cell Function and Binds Secretory IgA. Stuti Agarwal, Zachary Kraus, Jessica Dement-Brown, Oyeleye Alabi, Kyle Starost, Mate Tolnay. Cell reports. 2020 February;30:1292-1299.e3. [Full Text Article] [PubMed:32023449] Related Antibodies: LS-C666347.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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