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JAG1 / Jagged 1

jagged 1

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).

Gene Name: jagged 1
Synonyms: JAG1, AGS, AHD, Alagille syndrome, CD339 antigen, HJ1, Jagged1, JAGL1, Jagged, Jagged 1, Protein jagged-1, AWS, CD339, Soluble protein jagged
Target Sequences: NM_000214 NP_000205.1 P78504

Publications (7)

1
Differential expression of Notch receptors and their ligands in desmoplastic ameloblastoma. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2010 39:552-8. (IHC-P; Human) [PubMed:20337864] Related Antibodies: LS-B2442.
2
Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype. Siar CH, Nagatsuka H, Chuah KS, Rivera RS, Nakano K, Ng KH, Kawakami T. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2010 110:224-33. (IHC-P; Human) [PubMed:20659700] Related Antibodies: LS-B2442.
3
Immunolocalization of notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor. Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, Ng KH, Kawakami T. European journal of medical research. 2010 15:456-60. (IHC-P; Human) [Full Text Article] [PubMed:21156405] [PMC:PMC3352190] Related Antibodies: LS-B2442.
4
Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor. Siar CH, Kawakami T, Buery RR, Nakano K, Tomida M, Tsujigiwa H, Han PP, Nagatsuka H, Ng KH. European journal of medical research. 2011 16:501-6. (IHC-P; Human) [PubMed:22027644] [PMC:PMC3351808] Related Antibodies: LS-B2442.
5
Notch1 pathway in adrenocortical carcinomas: correlations with clinical outcome. Ronchi CL, Sbiera S, Altieri B, Steinhauer S, Wild V, Bekteshi M, Kroiss M, Fassnacht M, Allolio B. Endocrine-related cancer. 2015 22:531-43. (WB; Human) [Full Text Article] [PubMed:25979380]
6
Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Lewis PL, Su J, Yan M, Meng F, Glaser SS, Alpini GD, Green RM, Sosa-Pineda B, Shah RN. Scientific reports. 2018 August;8:12220. [Full Text Article] [PubMed:30111800] [PMC:PMC6093899]
7
3D mouse embryonic stem cell culture for generating inner ear organoids. Karl R Koehler, Eri Hashino. Nature protocols. 2014 May;9:1229-44. [Full Text Article] [PubMed:24784820] [PMC:PMC6453571]
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☰ Filters
Products
Proteins (16)
Over-Expression Lysate (2)
Recombinant (14)
JAG1 / Jagged 1 (16)
No (16)
10His-SUMO, N-terminus + Myc, C-terminus (1)
Fc (1)
Fc, C-terminus (2)
GST, N-terminus (2)
His (4)
His-T7 (1)
Human IgG Fc, C-terminus (1)
Human IgG1 Fc (1)
Myc-DDK (Flag) (3)
Human (12)
Mouse (3)
293T Cells (1)
E. coli (5)
HEK 293 Cells (4)
Human Cells (3)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (6)
Low endotoxin level (6)
Select
HEK 293 Cells
Human IgG Fc, C-terminus
Less than 0.01 EU/µg protein (determined by LAL method).
~150 kDa (SDS-PAGE)
10 µg/$347; 50 µg/$498
JAG1 / Jagged 1 Protein - Adipogenesis inhibition of 3T3L-1 cells. 3T3L1 cells were maintained in DMEM supplemented with 10% FBS and penicillin-streptomycin. When the cells were confluently grown adipogenesis was initiated by adding IBMX, Dexamethasone, and insulin to 0.5mM, 1 uM, and 10 ug/ml, respectively and continued for 2 days (day 0). The medium was replaced every 2 days with new medium containing insulin in the presence or absence of 5 ug/ml of human Jagged1-Fc and human CD137-Fc as a control-Fc. Staining with Oil Red O was typically performed on day 7.
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~150kDa (SDS-PAGE)
50 µg/$470; 10 µg/$347
JAG1 / Jagged 1 Protein - Recombinant Jagged 1 Protein By SDS-PAGE
Select
E. coli
His-T7
32.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
138.5 kDa
10 µg/$317; 50 µg/$524
JAG1 / Jagged 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
JAG1 / Jagged 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
JAG1 / Jagged 1 Protein - Purified recombinant protein JAG1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
133.6 kDa
20 µg/$1,107
JAG1 / Jagged 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
JAG1 / Jagged 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
133.6 kDa
20 µg/$150
JAG1 / Jagged 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
133.6 kDa
100 µg/$494
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
112 kDa
50 µg/$710; 500 µg/$2,696
Select
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
137 kDa
100 µg/$721
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
138.5kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
His
25.8 kDa
10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966
Select
E. coli
His
41.0 kDa
10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966
JAG1 / Jagged 1 Protein - Recombinant Jagged 1 Protein By SDS-PAGE
Select
E. coli
His
24.6 kDa
10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).