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IZUMO1 / IZUMO

izumo sperm-egg fusion 1

Essential sperm cell-surface protein required for fertilization by acting as a ligand for FOLR4/JUNO receptor on egg. The IZUMO1:FOLR4/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.

Gene Name:	izumo sperm-egg fusion 1
Synonyms:	IZUMO1, IZUMO, Oocyte binding/fusion factor, OBF, Sperm-specific protein izumo, Izumo sperm-egg fusion 1
Target Sequences:	AA383134 Q8IYV9 Q8IYV9

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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