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IYD

Iodotyrosine deiodinase

IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.

Gene Name: Iodotyrosine deiodinase
Synonyms: IYD, DJ422F24.1, IYD-1, Iodotyrosine dehalogenase 1, Iodotyrosine deiodinase, TDH4, C6orf71, DEHAL1
Target Sequences: Q6PHW0 Q6PHW0

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).