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ITPR2 / IP3 Receptor Type 2

inositol 1,4,5-trisphosphate receptor, type 2

ITPR2 / IP3 Receptor Type 2 belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

Gene Name: inositol 1,4,5-trisphosphate receptor, type 2
Family/Subfamily: Ion Channel , Inositol 1,4,5-triphosphate receptor
Synonyms: ITPR2, IP3R 2, InsP3R2, IP3R2, InsP3R type II, IP3 receptor, InsP3R type 2, IP3 receptor isoform 2, Type 2 InsP3 receptor
Target Sequences: NM_002223 NP_002214.2 Q14571

Publications (1)

1
Shared functional defect in IP₃R-mediated calcium signaling in diverse monogenic autism syndromes. Schmunk G, Boubion BJ, Smith IF, Parker I, Gargus JJ. Translational psychiatry. 2015 5:e643. (ICC; Rat) [Full Text Article] [PubMed:26393489] [PMC:PMC5068815] Related Antibodies: LS-C24911.

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ITPR2 / IP3 Receptor Type 2 ELISA Kit
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123.5 - 10000 pg/ml
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).