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ITPR2 / IP3 Receptor Type 2

inositol 1,4,5-trisphosphate receptor, type 2

ITPR2 / IP3 Receptor Type 2 belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

Gene Name: inositol 1,4,5-trisphosphate receptor, type 2
Family/Subfamily: Ion Channel , Inositol 1,4,5-triphosphate receptor
Synonyms: ITPR2, IP3R 2, InsP3R2, IP3R2, InsP3R type II, IP3 receptor, InsP3R type 2, IP3 receptor isoform 2, Type 2 InsP3 receptor
Target Sequences: NM_002223 NP_002214.2 Q14571

Publications (1)

1
Shared functional defect in IP₃R-mediated calcium signaling in diverse monogenic autism syndromes. Schmunk G, Boubion BJ, Smith IF, Parker I, Gargus JJ. Translational psychiatry. 2015 5:e643. (ICC; Rat) [Full Text Article] [PubMed:26393489] [PMC:PMC5068815] Related Antibodies: LS-C24911.

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Products
Antibodies (14)
Primary (14)
ITPR2 / IP3 Receptor Type 2 (14)
Human (13)
Mouse (9)
Rat (9)
Bovine (3)
Chimpanzee (3)
Gibbon (3)
Guinea pig (3)
Hamster (1)
Horse (3)
Monkey (5)
Rabbit (3)
IHC (8)
IHC-P (2)
WB (10)
ELISA (5)
ICC (2)
IF (1)
IP (1)
Peptide-ELISA (2)
rabbit (12)
goat (1)
rabbit-new zealand white (1)
Product Group
IHCPlus (2)
IgG (5)
polyclonal pc (14)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (11)
C-Terminus (4)
aa53-102 (4)
aa1150-1200 (1)
aa1152-1164 (1)
No (13)
Yes (1)
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Rat, Hamster, Human, Monkey
ICC, IF, IHC, IP, WB
Unconjugated
50 µl/$702
ITPR2 / IP3 Receptor Type 2 Antibody - Anti-ITPR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
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ITPR2 / IP3 Receptor Type 2 Goat anti-Human Polyclonal (aa1152-1164) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$379
ITPR2 / IP3 Receptor Type 2 Antibody - Anti-ITPR2 / IP3 Receptor antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ITPR2 / IP3 Receptor Type 2 Antibody - ITPR2 / IP3 Receptor antibody Western Blot of Fetal Small Intestine. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (aa53-102) Antibody
Human
WB
Unconjugated
100 µl/$424
ITPR2 / IP3 Receptor Type 2 Antibody - ITPR2 / IP3 Receptor antibody Western Blot of Fetal Small Intestine. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (aa53-102) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
ITPR2 / IP3 Receptor Type 2 Antibody - ITPR2 / IP3 Receptor antibody Western Blot of Fetal Small Intestine. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (aa53-102) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
ITPR2 / IP3 Receptor Type 2 Antibody - ITPR2 / IP3 Receptor antibody Western Blot of Fetal Small Intestine. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal (aa53-102) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Horse, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
Select
ITPR2 / IP3 Receptor Type 2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
ITPR2 / IP3 Receptor Type 2 Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using ITPR2 Polyclonal Antibody at dilution of 1:40.
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ITPR2 / IP3 Receptor Type 2 Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using ITPR2 Polyclonal Antibody at dilution of 1:60(×200)
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ITPR2 / IP3 Receptor Type 2 Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using ITPR2 Polyclonal Antibody at dilution of 1:65(×200)
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
ITPR2 / IP3 Receptor Type 2 Rabbit-New Zealand White anti-Human Polyclonal (aa1150-1200) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
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ITPR2 / IP3 Receptor Type 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).