ITPK1

inositol-tetrakisphosphate 1-kinase

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

ITPK1 (8)

Publications

No (8)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ITPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81627

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$150

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Human ITPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81629

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$150

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Human ITPK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68191

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$1,107

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Human ITPK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68192

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

20 µg/$1,107

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Human ITPK1 Protein (Recombinant GST) (Full Length) - LS-G29098

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.28 kDa

Price:

10 µg/$479; 25 µg/$670

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ITPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126031

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

100 µg/$494

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ITPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114096

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.4 kDa

Price:

100 µg/$494

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Human ITPK1 Protein (Recombinant His) - LS-G1873

Source:

E. coli

Tag:

His

Price:

100 µg/$411; 500 µg/$985; 20 µg/$276

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