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ITPK1

inositol-tetrakisphosphate 1-kinase

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca2+-activated Cl- channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Gene Name: inositol-tetrakisphosphate 1-kinase
Synonyms: ITPK1, ITRPK1, Ins(1,3,4)P(3) 5/6-kinase
Target Sequences: NM_014216 NP_055031.2 Q13572

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Products
Antibodies (43)
Primary (43)
ITPK1 (43)
Human (43)
Mouse (14)
Rat (8)
Bat (3)
Bovine (6)
Chimpanzee (6)
Dog (6)
Guinea pig (6)
Horse (6)
Monkey (3)
Pig (6)
Rabbit (6)
IHC (5)
IHC-P (3)
WB (43)
ELISA (16)
ICC (1)
IF (2)
IP (1)
Peptide-ELISA (3)
rabbit (34)
mouse (9)
Product Group
IHCPlus (1)
IgG (33)
IgG1 (2)
IgG3,k (6)
monoclonal mc (8)
polyclonal pc (35)
OTI1F5 (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (22)
aa28-54 (7)
aa179-228 (4)
aa36-85 (4)
aa309-391 (2)
50-130 aa, Internal (1)
aa171-414 (1)
aa52-101 (1)
aa81-130 (1)
No (43)
ITPK1 Antibody - Immunohistochemistry of paraffin-embedded human liver tissue at dilution 1:100
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
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ITPK1 Mouse anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$705
ITPK1 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ITPK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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ITPK1 Mouse anti-Human Monoclonal (aa309-391) (OTI1F5) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
ITPK1 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ITPK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
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ITPK1 Mouse anti-Human Monoclonal (aa309-391) (Carrier-free) (OTI1F5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ITPK1 Antibody - Immunofluorescence of paraformaldehyde-fixed HeLa using ITPK1 antibody at 1:200 dilution.
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ITPK1 Rabbit anti-Human Polyclonal (aa171-414) Antibody
Human
ICC, WB
Unconjugated
100 µl/$450
ITPK1 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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ITPK1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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ITPK1 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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ITPK1 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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ITPK1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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ITPK1 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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ITPK1 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
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ITPK1 Rabbit anti-Human Polyclonal (aa28-54) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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ITPK1 Rabbit anti-Human Polyclonal (aa28-54) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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ITPK1 Rabbit anti-Human Polyclonal (aa28-54) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
ITPK1 Rabbit anti-Human Polyclonal (aa28-54) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
ITPK1 Rabbit anti-Human Polyclonal (aa28-54) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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ITPK1 Rabbit anti-Human Polyclonal (aa28-54) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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ITPK1 Rabbit anti-Human Polyclonal (50-130 aa, Internal) Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
ITPK1 Antibody - Western blot analysis of extracts from HeLa cells, HepG2 cells and Jurkat cells, using ITPK1 antibody.
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
ITPK1 Antibody - Western blot analysis of the lysates from HepG2 cells using ITPK1 antibody.
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ITPK1 Rabbit anti-Human Polyclonal (aa52-101) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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ITPK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Viewing 26-43 of 43 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).