ITK / EMT

IL2-inducible T-cell kinase

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ITK / EMT (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ITK / EMT Protein (Recombinant GST) (Full Length) - LS-G29100

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.2 kDa

Price:

2 µg/$439

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Mouse ITK / EMT Protein (Recombinant His-S) (aa368-625) - LS-G25919

Source:

E. coli

Tag:

His-S

Molecular Weight:

89.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human ITK / EMT Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67237

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.7 kDa

Price:

20 µg/$1,107

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Human ITK / EMT Protein (Recombinant GST, N-terminus) (aa1-111) - LS-G59034

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ITK / EMT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79398

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.7 kDa

Price:

20 µg/$215

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ITK / EMT Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100590

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.7 kDa

Price:

100 µg/$710

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