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ITK / EMT

IL2-inducible T-cell kinase

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation.

Gene Name: IL2-inducible T-cell kinase
Family/Subfamily: Protein Kinase , BTK/TEC
Synonyms: ITK, Emt/Itk/Tsk, IL-2-inducible T-cell kinase, IL2-inducible T-cell kinase, Kinase EMT, LYK, T-cell-specific kinase, PSCTK2, T-Cell Tyrosine Kinase EMT, EMT, IL-2-inducible T cell kinase, Tyrosine-protein kinase Lyk
Target Sequences: NM_005546 NP_005537.3 Q08881

Publications (1)

1
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. Huck K, Feyen O, Niehues T, Rschendorf F, Hbner N, Laws HJ, Telieps T, Knapp S, Wacker HH, Meindl A, Jumaa H, Borkhardt A. The Journal of clinical investigation. 2009 119:1350-8. (WB) [PubMed:19425169] [PMC:PMC2673872]

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ITK / EMT ELISA Kit
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).