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ITGB7 / Integrin Beta 7

integrin, beta 7

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Gene Name: integrin, beta 7
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGB7, Integrin Beta 7, Integrin beta 7 subunit, Integrin beta-7, Integrin, beta 7, INTEGRINB7, Integrin B7, Integrin B 7
Target Sequences: NM_000889 NP_000880.1 P26010

Publications (1)

1
IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, Wang D, Huang H. Journal of immunology (Baltimore, Md. : 1950). 2009 182:2835-41. [PubMed:19234178] [PMC:PMC2756103] Related Antibodies: LS-C41345.

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Proteins (5)
Over-Expression Lysate (2)
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ITGB7 / Integrin Beta 7 (5)
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GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
ITGB7 / Integrin Beta 7 Protein - 12.5% SDS-PAGE of human ITGB7 stained with Coomassie Blue
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Wheat Germ Extract
GST
113.3 kDa
2 µg/$439
ITGB7 / Integrin Beta 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
86.7 kDa
20 µg/$150
ITGB7 / Integrin Beta 7 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ITGB7 / Integrin Beta 7 Protein - Purified recombinant protein ITGB7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
86.7 kDa
20 µg/$1,107
ITGB7 / Integrin Beta 7 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
86.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).