ITGB3BP

Beta 3-endonexin (ITGB3BP)

Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

ITGB3BP (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (3)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human ITGB3BP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88129

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

20 µg/$150

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Human ITGB3BP Protein (Recombinant GST) (Full Length) - LS-G32838

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ITGB3BP Protein (Recombinant GST, N-terminus) (aa1-177) - LS-G57551

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ITGB3BP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70835

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

20 µg/$1,107

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Human ITGB3BP Protein (Recombinant GST, N-terminus) (aa78-177) - LS-G61991

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ITGB3BP Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61992

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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ITGB3BP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101188

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20 kDa

Price:

100 µg/$494

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