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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ITGB3 / Integrin Beta 3 / CD61

integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Gene Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGB3, BDPLT2, CD61 antigen, GT, gp3A, CD61, GPIIIa, Integrin beta-3
Target Sequences: NM_000212 NP_000203.2 P05106

Publications (1)

1
Abnormal whole blood thrombi in humans with inherited platelet receptor defects. Castellino FJ, Liang Z, Davis PK, Balsara RD, Musunuru H, Donahue DL, Smith DL, Sandoval-Cooper MJ, Ploplis VA, Walsh M. PloS one. 2012 7:e52878. [PubMed:23300803] [PMC:PMC3532496] Related Antibodies: LS-C165324.

Viewing 1-25 of 195 items
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
Unconjugated
50µg   0.9mg/ml   $425.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-CD61 antibody IHC of human placenta, terminal villi, red blood cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Anti-Integrin Beta 3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Mouse Monoclonal [clone VI-PL2] (IgG1,k) to Human ITGB3 / Integrin Beta 3 / CD61
Human
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $425.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human ITGB3 / Integrin Beta 3 / CD61
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Mouse Monoclonal [clone Y2/51] (IgG1) to Human ITGB3 / Integrin Beta 3 / CD61
Human
Flo, IHC-Fr, IHC-P
Unconjugated
0.05mg   $425.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Immunohistochemical analysis of CD61 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - IHC of CD61 on FFPE Bone Marrow tissue.
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Mouse Monoclonal [clone 2f2] (IgG1,k) to Human ITGB3 / Integrin Beta 3 / CD61
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1ml   $245.00; 0.5ml   $345.00
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Mouse Monoclonal [clone JM2E5] (IgG1) to Pig ITGB3 / Integrin Beta 3 / CD61
Dog, Bovine, Pig, Horse, Human
Flo
FITC Conjugated
100µg   0.1mg/ml   $905.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - ITGB3 / Integrin Beta 3 / CD61 antibody. IHC(P): Human Breast Cancer Tissue.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
ITGB3 / Integrin Beta 3 / CD61 Antibody
Select
Rat Monoclonal [clone 1-55-4] (IgG2a,k) to Mouse ITGB3 / Integrin Beta 3 / CD61
Mouse
Flo, IP, WB
Unconjugated
100µg   1mg/ml   $345.00
Select
Hamster Monoclonal [clone HM beta 3.1] (IgG) to Mouse ITGB3 / Integrin Beta 3 / CD61
Mouse
Flo
FITC Conjugated
0.1mg   $365.00
ITGB3 / Integrin Beta 3 / CD61 Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with ITGB3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Rabbit Polyclonal to Human ITGB3 / Integrin Beta 3 / CD61
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal [clone PM6/13] (IgG1) to Human ITGB3 / Integrin Beta 3 / CD61
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg   $385.00

Viewing 1-25 of 195 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).