ITGB1BP1 / ICAP1

integrin beta 1 binding protein 1

Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin-and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

ITGB1BP1 / ICAP1 (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (2)

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Human ITGB1BP1 / ICAP1 Protein (Recombinant GST, N-terminus) (aa101-200) - LS-G61056

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ITGB1BP1 / ICAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80187

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16 kDa

Price:

20 µg/$150

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Human ITGB1BP1 / ICAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80186

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.6 kDa

Price:

20 µg/$150

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Human ITGB1BP1 / ICAP1 Protein (Recombinant GST) (Full Length) - LS-G31562

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.74 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ITGB1BP1 / ICAP1 Protein (Recombinant GST) (Full Length) - LS-G31563

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.2 kDa

Price:

2 µg/$439

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Human ITGB1BP1 / ICAP1 Protein (Recombinant His, N-Terminal) - LS-G143879

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

21.8 kDa

Price:

50 µg/$419

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ITGB1BP1 / ICAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110352

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16 kDa

Price:

100 µg/$494

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ITGB1BP1 / ICAP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116437

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.6 kDa

Price:

100 µg/$494

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