Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
|Gene Name:||integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)|
|Family/Subfamily:||Integrin , not assigned-Integrin|
|Synonyms:||ITGAE, CD103, CD103 antigen, Integrin alpha-E, HML-1 antigen, Integrin alpha-IEL, Alpha polypeptide), Mucosal lymphocyte 1 antigen, HUMINAE|
|Target Sequences:||NM_002208 NP_002199.3 P38570|
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