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ITGA6/Integrin Alpha 6/CD49f

integrin, alpha 6

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: integrin, alpha 6
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA6, CD49f, CD49f antigen, Integrin alpha6B, Integrin, alpha 6, Integrin alpha-6 precursor, VLA-6, Integrin alpha-6, ITGA6B
Target Sequences: NM_000210 NP_000201.2 P23229

Publications (7)

1
Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH. Journal of cell science. 2007 120:2851-63. [PubMed:17666434]
2
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:5774-9. (IHC) [PubMed:18391223] [PMC:PMC2311360]
3
Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Nardella C, Carracedo A, Alimonti A, Hobbs RM, Clohessy JG, Chen Z, Egia A, Fornari A, Fiorentino M, Loda M, Kozma SC, Thomas G, Cordon-Cardo C, Pandolfi PP. Science signaling. 2009 2:ra2. [PubMed:19176516] [PMC:PMC2906144]
4
Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo. Xu T, Xu Y, Liao CP, Lau R, Goldkorn A. Molecular cancer therapeutics. 2010 9:438-49. [PubMed:20124445] [PMC:PMC2820598]
5
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Grange C, Tapparo M, Collino F, Vitillo L, Damasco C, Deregibus MC, Tetta C, Bussolati B, Camussi G. Cancer research. 2011 71:5346-56. [PubMed:21670082]
6
Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptor. Lai KP, Yamashita S, Vitkus S, Shyr CR, Yeh S, Chang C. Molecular endocrinology (Baltimore, Md.). 2012 26:52-66. [PubMed:22135068] [PMC:PMC3248327]
7
Immunocytochemical stem cell markers can predict clinical stage of breast cancer. Pedro J Gutiérrez Diez, Yanrong Su, Jose Russo. Oncology reports. 2017 Sep;38:1507-1516. [Full Text Article] [PubMed:28714035] Related Antibodies: LS-A8769.
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Proteins (5)
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ITGA6/Integrin Alpha 6/CD49f (5)
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HEK 293 Cells (2)
Wheat Germ Extract (1)
ITGA6/Integrin Alpha 6/CD49f Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
119.48 kDa
20 µg/$215
ITGA6/Integrin Alpha 6/CD49f Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ITGA6/Integrin Alpha 6/CD49f Protein - Purified recombinant protein ITGA6 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
117.2 kDa
20 µg/$1,107
ITGA6/Integrin Alpha 6/CD49f Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
119.48 kDa
100 µg/$710
ITGA6/Integrin Alpha 6/CD49f Protein - Recombinant Integrin Alpha 6 By SDS-PAGE
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E. coli
His-GST
52.0 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).