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ITGA5/Integrin Alpha 5/CD49e

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

ITGA5/Integrin Alpha 5/CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes.

Gene Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA5, FNRA, Integrin alpha-5, Integrin Alpha 5, Integrin alpha-F, VLA-5, CD49e, CD49e antigen, VLA5A
Target Sequences: NM_002205 NP_002196.2 P08648

Publications (3)

1
Correction to: In vivo imaging of early stages of rheumatoid arthritis by a5ß1-integrin-targeted positron emission tomography. Notni J, Gassert FT, Steiger K, Sommer P, Weichert W, Rummeny EJ, Schwaiger M, Kessler H, Meier R, Kimm MA. EJNMMI research. 2019 December;9:107. [Full Text Article] [PubMed:31828445] [PMC:PMC6906272] Related Antibodies: LS-B6179.
2
Development of the Fibronectin-Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker a5ß1 Integrin. Zhao-Hui Jin, Takako Furukawa, Katsushi Kumata, Lin Xie, Joji Yui, Hidekatsu Wakizaka, Yasuhisa Fujibayashi, Ming-Rong Zhang, Tsuneo Saga. Biological & pharmaceutical bulletin. 2015 August;38:1722-31. [Full Text Article] [PubMed:26277991]
3
Complementary, Selective PET Imaging of Integrin Subtypes a5ß1 and avß3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin. Johannes Notni, Katja Steiger, Frauke Hoffmann, Dominik Reich, Tobias G Kapp, Florian Rechenmacher, Stefanie Neubauer, Horst Kessler, Hans-Jürgen Wester. The Breast : official journal of the European Society of Mastology. 2016 Mar;;57:460-6. [Full Text Article] [PubMed:26635338] Related Antibodies: LS-B6179.

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Proteins (8)
Over-Expression Lysate (2)
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ITGA5/Integrin Alpha 5/CD49e (8)
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6His, C-terminus (2)
His-GST (3)
Myc-DDK (Flag) (3)
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E. coli (3)
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Mammalian Cells (1)
Purified (1)
Low endotoxin level (2)
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
105.1 kDa
10 µg/$288; 50 µg/$436
ITGA5/Integrin Alpha 5/CD49e Protein - Purified recombinant protein ITGA5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
110 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
114.54 kDa
20 µg/$150
ITGA5/Integrin Alpha 5/CD49e Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
114.54 kDa
100 µg/$494
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
105.11kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
ITGA5/Integrin Alpha 5/CD49e Protein - Recombinant Integrin Alpha 5 By SDS-PAGE
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E. coli
His-GST
61.6 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
ITGA5/Integrin Alpha 5/CD49e Protein - Recombinant Integrin Alpha 5 By SDS-PAGE
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E. coli
His-GST
50.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
ITGA5/Integrin Alpha 5/CD49e Protein - Recombinant Integrin Alpha 5 By SDS-PAGE
Select
E. coli
His-GST
50.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).