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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function. Alpha 4 combines with beta 1 (ITGB1) on T-cells to form the integrin very late (activation) antigen 4 (VLA-4) that can bind to the extracellular matrix molecules fibronectin or thrombospondin, and is also a ligand for the cell surface molecule vascular cell adhesion molecule 1 (VCAM-1). In addition, alpha 4 combines with beta 7 to form the lymphocyte homing receptor known as LPAM-1 (lymphocyte Peyer Patch adhesion molecule 1). Integrins are also known to participate in cell-surface mediated signalling.
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells. Kleinewietfeld M, Starke M, Di Mitri D, Borsellino G, Battistini L, Rtzschke O, Falk K. Blood. 2009 113:827-36.
[PubMed:18941119]
Related Antibodies: LS-C40971.
2
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease. Palacios F, Moreno P, Morande P, Abreu C, Correa A, Porro V, Landoni AI, Gabus R, Giordano M, Dighiero G, Pritsch O, Oppezzo P. Blood. 2010 115:4488-96.
[PubMed:20233972]
Related Antibodies: LS-C40971.
3
Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells. Mattapallil MJ, Silver PB, Mattapallil JJ, Horai R, Karabekian Z, McDowell JH, Chan CC, James EA, Kwok WW, Sen HN, Nussenblatt RB, David CS, Caspi RR. Journal of immunology (Baltimore, Md. : 1950). 2011 187:1977-85.
[PubMed:21765017]
[PMC:PMC3150271]
Related Antibodies: LS-C40971.
4
Syndecan-1 (CD138) Suppresses Apoptosis in Multiple Myeloma by Activating IGF1 Receptor: Prevention by SynstatinIGF1R Inhibits Tumor Growth. Beauvais DM, Jung O, Yang Y, Sanderson RD, Rapraeger AC. Cancer research. 2016 76:4981-93. (IP; Human)[Full Text Article]
[PubMed:27364558]
[PMC:PMC5010496]
5
Clinical relevance of integrin alpha 4 in gastrointestinal stromal tumours. Pulkka OP, Mpindi JP, Tynninen O, Nilsson B, Kallioniemi O, Sihto H, Joensuu H. Journal of cellular and molecular medicine. 2018 April;22:2220-2230. (Human)[Full Text Article]
[PubMed:29377440]
[PMC:PMC5867167]
Related Antibodies: LS-A9385.
6
Renal denervation and CD161a immune ablation prevent cholinergic hypertension and renal sodium retention. Nandita Raikwar, Cameron Braverman, Peter M Snyder, Robert A Fenton, David K Meyerholz, Francois M Abboud, Sailesh C Harwani. American journal of physiology. Heart and circulatory physiology. 2019 September;317:H517-H530. [Full Text Article]
[PubMed:31172810]
[PMC:PMC6766722]
Related Antibodies: LS-C192282.
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).