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ITGA2 / CD49b

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

ITGA2 encodes integrin alpha chain 2. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Family/Subfamily: Integrin , not assigned-Integrin
Synonyms: ITGA2, Alpha2 integrin, BR, CD49b antigen, CD49B, Integrin alpha2, Integrin Alpha 2, Integrin alpha-2, HPA-5, VLA-2, VLAA2, VLA-2 subunit alpha, Collagen receptor, GPIa, Platelet antigen Br, Platelet glycoprotein GPIa, VLA2 receptor, alpha-2 subunit
Target Sequences: NM_002203 CAA34894.1 P17301

Publications (1)

1
Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells. Kirkland SC, Ying H. The Journal of biological chemistry. 2008 283:27612-9. [PubMed:18664572] [PMC:PMC2562061]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).