ITCH / AIP4

itchy E3 ubiquitin protein ligase

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T-helper (TH2) cytokine development through its ability to induce JUNB ubiquitination and degradation (By similarity). Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteasomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteasomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteasomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

ITCH / AIP4 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ITCH / AIP4 Protein (Recombinant GST, N-terminus) (aa92-190) - LS-G63318

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ITCH / AIP4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80552

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.5 kDa

Price:

20 µg/$215

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ITCH / AIP4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102004

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.5 kDa

Price:

100 µg/$710

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Human ITCH / AIP4 Protein (Recombinant) (Arg526-Glu903) - LS-G97625

Source:

E. coli

Tag:

None

Molecular Weight:

40 kDa

Price:

100 µg/$843

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