IRS4

insulin receptor substrate 4

Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

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Products

ELISA Kits (3)

Type

Competitive EIA (1)

Custom (2)

Target

IRS4 (3)

Reactivity

Human (1)

Mouse (1)

Pig (1)

Format

96-Well Strip Plate (3)

Publications

No (3)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

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Pig IRS4 (Competitive EIA) ELISA Kit - LS-F38876

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

246.9 - 20000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$852

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Human IRS4 (Custom ELISA) ELISA Kit - LS-F14209

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse IRS4 (Custom ELISA) ELISA Kit - LS-F14208

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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