IRF3

interferon regulatory factor 3

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

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Products

Proteins (14)

Type

Over-Expression Lysate (6)

Recombinant (8)

Target

IRF3 (14)

Product Group

Coronavirus Antibodies Proteins cDNAs (14)

SARS-CoV-2 Associated Proteins (14)

Publications

No (14)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (2)

His-T7 (2)

Myc-DDK (Flag) (8)

Species

Human (9)

Mouse (2)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

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Human IRF3 Protein (Recombinant GST) (Full Length) - LS-G29083

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse IRF3 Protein (Recombinant His-T7) (aa1-406) - LS-G14032

Source:

E. coli

Tag:

His-T7

Molecular Weight:

49.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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Human IRF3 Protein (Recombinant GST) (Full Length) - LS-G29081

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75.24 kDa

Price:

2 µg/$439

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Mouse IRF3 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa1-419) - LS-G57200

Source:

Yeast

Tag:

10His, N-terminus + Myc, C-terminus

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human IRF3 Protein (Recombinant His-T7) (aa1-360) - LS-G14033

Source:

E. coli

Tag:

His-T7

Molecular Weight:

43.8 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.6 kDa

Price:

100 µg/$494

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IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130923

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.4 kDa

Price:

100 µg/$494

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Human IRF3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66068

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.6 kDa

Price:

20 µg/$1,107

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Human IRF3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66067

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

20 µg/$1,107

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Human IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76845

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.4 kDa

Price:

20 µg/$150

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Human IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76846

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

33.6 kDa

Price:

20 µg/$150

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Human IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76847

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

20 µg/$150

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IRF3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99484

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47 kDa

Price:

100 µg/$494

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Human IRF3 Protein (Recombinant) - LS-G3483

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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