IRF3

interferon regulatory factor 3

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

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Products

ELISA Kits (12)

Type

Cell-Based (1)

Custom (4)

Sandwich (7)

Target

IRF3 (12)

Reactivity

Human (5)

Mouse (3)

Chicken (1)

Goat (1)

Pig (1)

Product Group

Coronavirus Detection (12)

ELISA Kits for Associated Targets (12)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (10)

Publications

No (12)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (2)

Plasma (5)

Serum (5)

Tissue Homogenates (5)

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Human IRF3 (Sandwich ELISA) ELISA Kit - LS-F4800

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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Human IRF3 (Sandwich ELISA) ELISA Kit - LS-F34739

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse IRF3 (Sandwich ELISA) ELISA Kit - LS-F34738

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse IRF3 (Sandwich ELISA) ELISA Kit - LS-F6088

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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Pig IRF3 (Custom ELISA) ELISA Kit - LS-F17484

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine IRF3 (Custom ELISA) ELISA Kit - LS-F17485

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Chicken IRF3 (Custom ELISA) ELISA Kit - LS-F17482

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Mouse IRF3 (Custom ELISA) ELISA Kit - LS-F17483

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human IRF3 (Sandwich ELISA) ELISA Kit - LS-F11837

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Goat IRF3 (Sandwich ELISA) ELISA Kit - LS-F31869

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Goat

Range:

3.12 - 200 mIU/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human IRF3 (Sandwich ELISA) ELISA Kit - LS-F38094

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human IRF3 (Cell-Based ELISA) ELISA Kit - LS-F2087

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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