IRF1 / MAR

interferon regulatory factor 1

Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

IRF1 / MAR (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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IRF1 / MAR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118129

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

100 µg/$494

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Human IRF1 / MAR Protein (Recombinant GST) (Full Length) - LS-G29079

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.38 kDa

Price:

2 µg/$439

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Human IRF1 / MAR Protein (Recombinant GST, N-terminus) (aa216-325) - LS-G59011

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IRF1 / MAR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66065

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

20 µg/$1,107

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Human IRF1 / MAR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76842

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.3 kDa

Price:

20 µg/$150

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Human IRF1 / MAR Protein (Recombinant His) - LS-G3480

Source:

E. coli

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human IRF1 / MAR Protein (Recombinant His) (aa11-276) - LS-G14001

Source:

E. coli

Tag:

His

Molecular Weight:

31.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse IRF1 / MAR Protein (Recombinant His-GST) (aa44-319) - LS-G14003

Source:

E. coli

Tag:

His-GST

Molecular Weight:

63.1 kDa

Price:

10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192

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