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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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IRAK2 / IRAK-2
interleukin-1 receptor-associated kinase 2
IRAK2, an IRAK type protein kinase, is a signal transducer for the immune response interleukin-1 receptor (IL-1R) signaling cascade. IRAK2 also has been associated with signaling cell death, potentially via the Fas-associated death domain protein/caspase-8 apoptotic pathway. Dominant negative forms of IRAK2 attenuate IL-1R-mediated NF-kappa B activation, suggesting that IRAK-2 may serve as a therapeutic target for inhibiting IL-1-induced inflammation.
| Gene Name: | interleukin-1 receptor-associated kinase 2 |
| Family/Subfamily: | Protein Kinase , IRAK(Pelle) |
| Synonyms: | IRAK2, Il1rak2, IRAK-2 |
| Target Sequences: | NM_001570 NP_001561.3 O43187 |
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