IRAK1 / IRAK

interleukin-1 receptor-associated kinase 1

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

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Products

Proteins (12)

Type

Over-Expression Lysate (7)

Recombinant (5)

Target

IRAK1 / IRAK (12)

Publications

No (12)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (8)

Species

Human (9)

Source

293T Cells (4)

E. coli (2)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human IRAK1 / IRAK Protein (Recombinant GST, N-terminus) (aa530-693) - LS-G59009

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87519

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

20 µg/$215

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Human IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87520

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

20 µg/$215

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Human IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87521

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

20 µg/$150

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Human IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87522

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.4 kDa

Price:

20 µg/$215

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Human IRAK1 / IRAK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70590

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

20 µg/$1,107

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Human IRAK1 / IRAK Protein (Recombinant GST) (Full Length) - LS-G29077

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

94.4 kDa

Price:

2 µg/$439

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IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99487

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76.4 kDa

Price:

100 µg/$710

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Human IRAK1 / IRAK Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G145072

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

104.4 kDa

Price:

50 µg/$419

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IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121036

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73.2 kDa

Price:

100 µg/$710

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IRAK1 / IRAK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121037

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.8 kDa

Price:

100 µg/$494

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Human IRAK1 / IRAK Protein (Recombinant His) (aa212-440) - LS-G13944

Source:

E. coli

Tag:

His

Molecular Weight:

27.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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