IPO13 / LGL2

importin 13

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

IPO13 / LGL2 (4)

Publications

No (4)

Tag

DDK,C-terminus (1)

GST (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human IPO13 / LGL2 Protein (Recombinant GST) (Full Length) - LS-G31755

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

134.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IPO13 / LGL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86622

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108 kDa

Price:

20 µg/$150

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Human IPO13 / LGL2 Protein (Recombinant DDK,C-terminus) - LS-G142450

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

108 kDa

Price:

20 µg/$677

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IPO13 / LGL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101244

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

108 kDa

Price:

100 µg/$494

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