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IPAF / NLRC4

NLR family, CARD domain containing 4

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adaptor molecules and proteases including several members of the caspase family. Another family of proteins that functions as a critical regulator of apoptosis and NF-kB signaling pathways is the CED-4/Apaf-1 (apoptosis protein activating factor-1) protein family. Ipaf (ICE protease activating factor) is a CED-4/Apaf-1 family member that activates caspase-1/ICE and can induce apoptosis in human cells in a caspase-1 dependent manner. Ipaf and caspase-1 are thought to interact with each other through the association of the Ipaf amino-terminal CARD (caspase recruitment domain) and amino-terminal CARD of caspase-1.

Gene Name: NLR family, CARD domain containing 4
Family/Subfamily: Apoptosis
Synonyms: NLRC4, CARD12, CLANA, CLANB, CLANC, CLAND, CLAN, CLR2.1, Clan protein, CLAN1, Ice protease-activating factor, NOD-like receptor C4, ICE-protease activating factor, IPAF
Target Sequences: NM_021209 NP_067032.3 Q9NPP4

Publications (3)

1
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection. Yu Guo, Longjun Li, Tao Xu, Xiaomin Guo, Chaoming Wang, Yihui Li, Yanan Yang, Dong Yang, Bin Sun, Xudong Zhao, Genze Shao, Xiaopeng Qi. The Journal of clinical investigation. 2020 December;130:6301-6316. [Full Text Article] [PubMed:33104527] [PMC:PMC7685759] Related Antibodies: LS-C148271.
2
Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming. Margaret M McDaniel, Leah C Kottyan, Harinder Singh, Chandrashekhar Pasare. Cell reports. 2020 May;31:107604. [Full Text Article] [PubMed:32375053] [PMC:PMC7325595] Related Antibodies: LS-C407885.
3
Staphylococcus aureus a-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides. Jie Ma, Erich Gulbins, Michael J Edwards, Charles C Caldwell, Martin Fraunholz, Katrin Anne Becker. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017 43:2170-2184. [Full Text Article] [PubMed:29069651] Related Antibodies: LS-C148271.

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IPAF / NLRC4 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
IPAF / NLRC4 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
IPAF / NLRC4 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
IPAF / NLRC4 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
IPAF / NLRC4 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
IPAF / NLRC4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
IPAF / NLRC4 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$902
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).