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INVS / Inversin

inversin

Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis.

Gene Name: inversin
Synonyms: INVS, INV, Inversin, Nephrocystin-2, NPH2, NPHP2, Inversion of embryonic turning, Nephronophthisis 2 (infantile)
Target Sequences: NM_014425 NP_055240.2 Q9Y283

☰ Filters
Products
Antibodies (17)
Primary (17)
INVS / Inversin (17)
Human (17)
Mouse (3)
Rat (9)
IHC (2)
IHC-P (1)
WB (14)
ELISA (6)
IF (2)
Peptide-ELISA (1)
rabbit (17)
IgG (7)
polyclonal pc (17)
APC (1)
APC Conjugated (1)
Biotin Conjugated (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (7)
aa1-237 (8)
No (17)
INVS / Inversin Antibody - Immunohistochemistry of paraffin-embedded human liver cancer at dilution 1:100
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INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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INVS / Inversin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
INVS / Inversin Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
INVS / Inversin Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
Select
INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
INVS / Inversin Antibody - Western blot analysis of extracts of HeLa cells using INVS antibody. The lane on the left was treated with blocking peptide.
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INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
INVS / Inversin Antibody
Select
INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
INVS / Inversin Antibody - Western blot analysis of extracts of various cell lines, using INVS antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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INVS / Inversin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) Antibody
Rat, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (HRP) Antibody
Rat, Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (Biotin) Antibody
Rat, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (FITC) Antibody
Rat, Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (APC, Cy7) Antibody
Rat, Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (Cy3) Antibody
Rat, Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (APC) Antibody
Rat, Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
INVS / Inversin Antibody - Western blot of INVS / Inversin antibody.
Select
INVS / Inversin Rabbit anti-Human Polyclonal (aa1-237) (PE) Antibody
Rat, Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).