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Insulin
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
| Gene Name: | Insulin |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | INS, IRDN, IDDM2, Preproinsulin, ILPR, Insulin, MODY10, Proinsulin |
| Target Sequences: | NM_000207 NP_000198.1 P01308 |
Publications (6)
1
Transgenic pigs with pancreas-specific expression of green fluorescent protein. Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H. The Journal of reproduction and development. 2014 60:230-7. (IHC; Pig)
[PubMed:24748398]
[PMC:PMC4085388]
Related Antibodies: LS-C24686.
2
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation. Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H. Stem cell reports. 2020 January;14:21-33. [Full Text Article]
[PubMed:31883918]
[PMC:PMC6962638]
Related Antibodies: LS-C24686.
3
Lipocalin-2 is an anorexigenic signal in primates. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. eLife. 2020 November;9: [Full Text Article]
[PubMed:33231171]
[PMC:PMC7685704]
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Products
Proteins
(22)
Type
Native
(2)
Over-Expression Lysate
(2)
Recombinant
(17)
Synthetic Peptide
(1)
Target
Insulin
(22)
Publications
No
(22)
Tag
10His, N-terminus + Myc, C-terminus
(1)
6His, N-terminus
(1)
6His, N-terminus + Myc, C-terminus
(1)
GST
(1)
His, N-Terminal
(3)
His-GST
(4)
His-GST, N-terminus
(2)
His-SUMO, N-terminus
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Cow
(1)
Guinea pig
(1)
Human
(9)
Mouse
(4)
Pig
(2)
Rabbit
(1)
Rat
(2)
Source
293T Cells
(1)
E. coli
(13)
HEK 293 Cells
(2)
Mammalian Cells
(1)
Synthetic
(1)
Wheat Germ Extract
(1)
Yeast
(2)
Purification
Purified
(10)
Biologically Active
Biologically active
(1)
E. coli
His, N-Terminal
9.9 kDa
10 µg/$276; 50 µg/$412; 200 µg/$822; 1 mg/$1,905; 5 mg/$2,871; 2 mg/$2,090
E. coli
6His, N-terminus
12 kDa
10 µg/$265; 50 µg/$315
E. coli
His, N-Terminal
10kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
Wheat Germ Extract
GST
38.4 kDa
10 µg/$479; 25 µg/$670
E. coli
None
Biologically active
5.8 kDa
25 mg/$455; 250 mg/$710; 1000 mg/$1,628
E. coli
His-GST
35.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
E. coli
His-GST
35.8 kDa
50 µg/$402; 10 µg/$275; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-SUMO, N-terminus
20kDa
10 µg/$273; 50 µg/$392; 200 µg/$782; 100 µg/$625; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029
HEK 293 Cells
Myc-DDK (Flag)
9.3 kDa
20 µg/$1,107
Yeast
6His, N-terminus + Myc, C-terminus
100 µg/$570; 20 µg/$395; 1 mg/$1,973
E. coli
10His, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
293T Cells
Myc-DDK (Flag)
11.98 kDa
20 µg/$150
E. coli
His-GST
34.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
E. coli
His-GST, N-terminus
41.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
E. coli
His-T7
17.0 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His-GST
41.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,601
None
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,838
Mammalian Cells
His, N-Terminal
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,838
E. coli
His-GST, N-terminus
36kDa
10 µg/$339; 50 µg/$802; 200 µg/$1,430; 100 µg/$1,214; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
HEK 293 Cells
Myc-DDK (Flag)
11.98 kDa
100 µg/$494
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