INSM1

insulinoma-associated 1

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

INSM1 (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

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Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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INSM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118134

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

100 µg/$710

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Human INSM1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67358

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

20 µg/$1,107

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Human INSM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79661

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

20 µg/$215

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