INSM1

insulinoma-associated 1

Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.

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Products

Antibodies (20)

Type

Primary (20)

Target

INSM1 (20)

Reactivity

Human (12)

Mouse (13)

Rat (1)

Bovine (3)

Chimpanzee (3)

Dog (3)

Monkey (3)

Pig (3)

Application

IHC (4)

IHC-Fr (2)

IHC-P (5)

WB (17)

ELISA (2)

Host

rabbit (18)

mouse (2)

Isotype

IgG (10)

IgG1,k (2)

Clonality

monoclonal mc (2)

polyclonal pc (18)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (3)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Ready-to-Use (1)

Unconjugated (7)

Epitope

C-Terminus (4)

aa191-240 (4)

Publications

No (20)

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INSM1 Antibody LS-C763394

Antibody:

INSM1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$311

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INSM1 Antibody LS-C663452

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571

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INSM1 Antibody (HRP) LS-C712826

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (HRP) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722

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INSM1 Antibody (Biotin) LS-C688161

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (Biotin) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611

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INSM1 Antibody (FITC) LS-C695079

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (FITC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777

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INSM1 Antibody (PE) LS-C726889

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030

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INSM1 Antibody (APC) LS-C741218

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (APC) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030

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INSM1 Antibody (APC, Cy7) LS-C735812

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441

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INSM1 Antibody (Cy3) LS-C703807

Antibody:

INSM1 Rabbit anti-Mouse Polyclonal (Cy3) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC
• APC, Cy7
• More...
  • Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC
  • APC, Cy7
  • Cy3

Select

INSM1 Antibody (aa191-240) LS-C31212

Antibody:

INSM1 Rabbit anti-Human Polyclonal (aa191-240) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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INSM1 Antibody (aa191-240, HRP) LS-C427191

Antibody:

INSM1 Rabbit anti-Human Polyclonal (aa191-240) (HRP) Antibody

Reactivity:

Mouse, Dog, Bovine, Pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$442

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INSM1 Antibody (aa191-240, Biotin) LS-C427189

Antibody:

INSM1 Rabbit anti-Human Polyclonal (aa191-240) (Biotin) Antibody

Reactivity:

Mouse, Dog, Bovine, Pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

INSM1 Antibody (aa191-240, FITC) LS-C427190

Antibody:

INSM1 Rabbit anti-Human Polyclonal (aa191-240) (FITC) Antibody

Reactivity:

Mouse, Dog, Bovine, Pig, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

INSM1 Antibody LS-C831629

Antibody:

INSM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

INSM1 Antibody LS-C108598

Antibody:

INSM1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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INSM1 Antibody (Ready-to-Use) LS-C763392

Antibody:

INSM1 Mouse anti-Human Monoclonal (Ready-to-Use) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated, Ready-to-Use

Price:

3 ml/$348

Select

INSM1 Antibody (C-Terminus) LS-C29921

Antibody:

INSM1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

INSM1 Antibody (C-Terminus, HRP) LS-C428337

Antibody:

INSM1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

INSM1 Antibody (C-Terminus, Biotin) LS-C428335

Antibody:

INSM1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

INSM1 Antibody (C-Terminus, FITC) LS-C428336

Antibody:

INSM1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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