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INSIG1
insulin induced gene 1
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
| Gene Name: | insulin induced gene 1 |
| Synonyms: | INSIG1, Cl-6, CL6, INSIG-1, Insulin induced gene 1, Insulin-induced gene 1 protein, INSIG-1 membrane protein |
| Target Sequences: | NM_005542 NP_005533.2 O15503 |
Publications (4)
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