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INHBB / Inhibin Beta B

inhibin, beta B

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

Gene Name: inhibin, beta B
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: INHBB, Activin beta-B chain, Activin AB beta polypeptide, Inhibin, beta B, Inhibin Beta B, Inhibin beta B chain, Inhibin, beta-2
Target Sequences: NM_002193 NP_002184.2 P09529

Publications (1)

1
Inhibin B in seminiferous tubules of human testes in normal spermatogenesis and in idiopathic infertility. Grigory A Demyashkin. Systems biology in reproductive medicine. 2019 Feb;65:20-28. [Full Text Article] [PubMed:29886763]

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INHBB / Inhibin Beta B (10)
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INHBB / Inhibin Beta B Protein - Recombinant Inhibin Beta B By SDS-PAGE
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E. coli
His
14.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
INHBB / Inhibin Beta B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
45.18 kDa
20 µg/$150
INHBB / Inhibin Beta B Protein - Recombinant Inhibin Beta B By SDS-PAGE
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E. coli
His, N-terminus
14.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
INHBB / Inhibin Beta B Protein - Recombinant Inhibin Beta B By SDS-PAGE
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E. coli
His-GST
72.6 kDa
50 µg/$382; 10 µg/$271; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
INHBB / Inhibin Beta B Protein - Recombinant Inhibin Beta B By SDS-PAGE
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E. coli
His
14.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
INHBB / Inhibin Beta B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.18 kDa
100 µg/$494
INHBB / Inhibin Beta B Protein - 12.5% SDS-PAGE of human INHBB stained with Coomassie Blue
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Wheat Germ Extract
GST
71.6 kDa
2 µg/$439
INHBB / Inhibin Beta B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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E. coli
His
14.3 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
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E. coli
His
14.3 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).