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ING4
inhibitor of growth family, member 4
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
| Gene Name: | inhibitor of growth family, member 4 |
| Synonyms: | ING4, Brain my036 protein, Inhibitor of growth protein 4, My036, p29ING4 |
| Target Sequences: | NM_016162 NP_057246.2 Q9UNL4 |
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