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ILT2 / CD85

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Gene Name: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
Synonyms: LILRB1, CD85, CD85j antigen, CD85J, Ig-like transcript 2, Leukocyte Ig-like receptor-1, LIR-1, LIR1, ILT-2, MIR-7, MIR7, ILT2
Target Sequences: Q8NHL6 Q8NHL6

Publications (2)

1
Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X. Levy E, Reger R, Segerberg F, Lambert M, Leijonhufvud C, Baumer Y, Carlsten M, Childs R. Frontiers in immunology. 2019 June;10: [Full Text Article] [PubMed:31231387] [PMC:PMC6560173]
2
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity. Caroline Leijonhufvud, Robert Reger, Filip Segerberg, Jakob Theorell, Heinrich Schlums, Yenan T Bryceson, Richard W Childs, Mattias Carlsten. Clinical & translational immunology. 2021 October;10:e1346. [Full Text Article] [PubMed:34631057] [PMC:PMC8491220] Related Antibodies: LS-C107050.

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
ILT2 / CD85 (9)
No (9)
6His, C-terminus (2)
AVI-6His, C-terminus (1)
Fc, C-terminus (1)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (8)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Human (2)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (4)
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.24kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
ILT2 / CD85 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
70.6 kDa
20 µg/$215
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.2 kDa
10 µg/$262; 50 µg/$361
ILT2 / CD85 Protein - Recombinant Human Leukocyte Ig-Like Receptor B1/ LILRB1/ILT2/CD85j (C-6His-Avi) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
50 kDa
20 µg/$416; 100 µg/$910
ILT2 / CD85 Protein - Recombinant Human Leukocyte Ig-Like Receptor B1/ LILRB1/ILT2/CD85j (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
74.1 kDa
10 µg/$266; 50 µg/$377
ILT2 / CD85 Protein - Purified recombinant protein LILRB1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
70.6 kDa
20 µg/$1,107
ILT2 / CD85 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
70.6 kDa
100 µg/$710
ILT2 / CD85 Protein - Recombinant Leukocyte Immunoglobulin Like Receptor Subfamily B, Member 1 By SDS-PAGE
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E. coli
His-T7
24.0 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ILT2 / CD85 Protein - 12.5% SDS-PAGE of human LILRB1 stained with Coomassie Blue
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Wheat Germ Extract
GST
95.26 kDa
10 µg/$479; 25 µg/$670
Viewing 1-9 of 9 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).