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ILK / Integrin Linked Kinase
integrin-linked kinase
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
| Gene Name: | integrin-linked kinase |
| Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
| Synonyms: | ILK, ILK-1, ILK2, Integrin-linked kinase-2, p59, Integrin-linked kinase 1, ILK-2, ILK1, Integrin-linked kinase, Integrin-linked protein kinase, p59ILK |
| Target Sequences: | NM_004517 NP_004508.1 Q13418 |
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