Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IL6ST / CD130 / gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
|Gene Name:||interleukin 6 signal transducer (gp130, oncostatin M receptor)|
|Synonyms:||IL6ST, CD130, CD130 antigen, IL-6R subunit beta, IL-6 receptor subunit beta, Membrane glycoprotein gp130, Membrane glycoprotein 130, IL-6RB, CDW130, gp130, IL-6R-beta|
|Target Sequences:||NM_002184 NP_002175.2 P40189|
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.