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IL6R / IL6 Receptor

interleukin 6 receptor

IL6R / IL6 Receptor is a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.

Gene Name: interleukin 6 receptor
Family/Subfamily: Interleukin
Synonyms: IL6R, CD126, gp80, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL6Q, IL-6 receptor subunit alpha, IL-6R 1, IL-6R-1, Interleukin 6 receptor, Membrane glycoprotein 80, CD126 antigen, IL6RA, IL6RQ
Target Sequences: NM_000565 NP_000556.1 P08887

Publications (2)

1
Interleukin 6 regulates psoriasiform inflammation-associated thrombosis. Wang Y, Golden JB, Fritz Y, Zhang X, Diaconu D, Camhi MI, Gao H, Dawes SM, Xing X, Ganesh SK, Gudjonsson JE, Simon DI, McCormick TS, Ward NL. JCI insight. 2016 1:e89384. (IHC-P; Human) [Full Text Article] [PubMed:27942589] [PMC:PMC5135273] Related Antibodies: LS-B6362.
2
Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. Wang X, Miller EB, Goswami M, Zhang P, Ronning KE, Karlen SJ, Zawadzki RJ, Pugh EN Jr, Burns ME. Journal of neuroinflammation. 2017 14:121. (WB; Mouse) [Full Text Article] [PubMed:28645275] [PMC:PMC5481880] Related Antibodies: LS-C70920.

☰ Filters
Products
Antibodies (132)
Primary (132)
IL6R / IL6 Receptor (132)
Human (59)
Mouse (35)
Rat (56)
IHC (20)
IHC-Fr (3)
IHC-P (5)
WB (95)
Flo (24)
Block (1)
ELISA (32)
Func (3)
ICC (6)
IF (5)
Inhb (1)
IP (13)
Neut (4)
Peptide-ELISA (3)
rabbit (99)
mouse (28)
goat (1)
human (1)
rat (3)
Product Group
Coronavirus Disease Inhibition (1)
IHCPlus (4)
IgG (18)
IgG1 (24)
IgG1,k (1)
IgG2a (3)
IgG2b,k (1)
monoclonal mc (30)
polyclonal pc (101)
recombinant monoclonal rmc (1)
17506 (1)
2G6 (1)
3H7D3H1 (1)
B-R6 (3)
OTI1B5 (2)
OTI2F4 (2)
rhPM-1 (Tocilizumab) (1)
APC (8)
APC Conjugated (12)
Biotin Conjugated (14)
Carrier-free (2)
CF Conjugated (1)
Cy3 Conjugated (8)
Cy7 Conjugated (8)
FITC Conjugated (13)
HRP Conjugated (11)
PE Conjugated (13)
Preservative Free (2)
Unconjugated (52)
aa214-348 (18)
aa385-462 (10)
aa19-108 (8)
aa19-348 (8)
aa205-347 (8)
aa216-356 (8)
aa52-204 (8)
aa1-365 (4)
Extracellular Domain (2)
IL-6 receptor (1)
aa192-458 (1)
aa20-320 (1)
aa221-270 (1)
aa23-371 (1)
aa23-617 (1)
aa246-260 (1)
aa379-419 (1)
No (130)
Yes (2)
IL6R / IL6 Receptor Antibody - Anti-IL6R antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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IL6R / IL6 Receptor Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$907
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (B-R6) Antibody
Human
ELISA, Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$385
IL6R / IL6 Receptor Antibody - IHC of paraffin-embedded Human lymph node tissue using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (OTI2F4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa19-108) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa19-108) (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$322; 200 µl/$370; 500 µl/$529; 1 ml/$614; 2 ml/$846; 5 ml/$1,395
IL6R / IL6 Receptor Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa216-356) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, ICC
Unconjugated
100 µg/$848
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$801
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (B-R6) Antibody
Human
ELISA, Flo, Func, IHC, IHC-Fr, IP
Unconjugated
100 µg/$597
IL6R / IL6 Receptor Antibody - Western Blot; Sample: Recombinant protein.
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IL6R / IL6 Receptor Rabbit anti-Rat Polyclonal (aa214-348) Antibody
Rat
WB
Unconjugated
100 µl/$312; 200 µl/$355; 500 µl/$500; 1 ml/$573; 2 ml/$780; 5 ml/$1,268
IL6R / IL6 Receptor Antibody - 1:100 staining human urothelial carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
IL6R / IL6 Receptor Antibody - Western Blot analysis of extracts from AD293, 4T1 cells using IL6R Antibody.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa221-270) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (17506) Antibody
Human
ELISA, Flo, Neut, WB
Unconjugated
100 µg/$962
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IL6R / IL6 Receptor Rat anti-Mouse Monoclonal (Extracellular Domain) Antibody
Mouse
Flo, ICC
Unconjugated
500 µg/$1,089
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa23-371) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$341
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
IL6R / IL6 Receptor Antibody - IF staining of U937 cells.
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IL6R / IL6 Receptor Human anti-Human Recombinant Monoclonal (IL-6 receptor) (rhPM-1 (Tocilizumab)) Antibody
Human
ELISA, Inhb
Unconjugated
0.2 mg/$540
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Mouse Polyclonal (aa205-347) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
IL6R / IL6 Receptor Antibody - Western blot of recombinant IL6R / IL6 Receptor.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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IL6R / IL6 Receptor Rabbit anti-Mouse Polyclonal (aa52-204) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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IL6R / IL6 Receptor Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, Flo, ICC, IF
Unconjugated
20 µl/$271; 100 µl/$412
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IL6R / IL6 Receptor Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$884
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa1-365) Antibody
Human
ELISA
Unconjugated
100 µl/$412
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IL6R / IL6 Receptor Goat anti-Mouse Polyclonal (aa246-260) Antibody
Mouse
Peptide-ELISA
Unconjugated
100 µg/$401
IL6R / IL6 Receptor Antibody - Western blot analysis of IL6R using anti-IL6R antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: human A549 whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-IL6R antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for IL6R at approximately 52KD. The expected band size for IL6R is at 52KD.
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IL6R / IL6 Receptor Rabbit anti-Human Polyclonal (aa379-419) Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
Viewing 1-25 of 132 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).