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IL6 / Interleukin 6
interleukin 6 (interferon, beta 2)
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
| Gene Name: | interleukin 6 (interferon, beta 2) |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | IL6, B-cell stimulatory factor 2, BSF-2, BSF2, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2, Interleukin-6, Interleukin BSF-2, IFNB2, B-cell differentiation factor, CDF, HSF, IL-6 |
| Target Sequences: | NM_000600 NP_000591.1 P05231 |
Publications (17)
1
Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. Chen C, Liu Y, Liu Y, Zheng P. The Journal of clinical investigation. 2010 120:4091-101. (Mouse)
[PubMed:20972332]
[PMC:PMC2964994]
Related Antibodies: LS-C7955.
2
Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis. Boonkasidecha S, Kannan PS, Kallapur SG, Jobe AH, Kemp MW. PloS one. 2017 September;12:e0184938. (Human)
[Full Text Article]
[PubMed:28957335]
[PMC:PMC5619751]
Related Antibodies: LS-B7482.
3
Contribution of the Interleukin-6/STAT-3 Signaling Pathway to Chondrogenic Differentiation of Human Mesenchymal Stem Cells. Kondo M, Yamaoka K, Sakata K, Sonomoto K, Lin L, Nakano K, Tanaka Y. Arthritis & rheumatology (Hoboken, N.J.). 2015 May;67:1250-60. [Full Text Article]
[PubMed:25604648]
☰ Filters
Products
Proteins
(77)
Type
Over-Expression Lysate
(2)
Recombinant
(75)
Target
IL6 / Interleukin 6
(77)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(2)
Product Group
Coronavirus Antibodies Proteins cDNAs
(76)
Cytokine Release Syndrome
(76)
Cytokine Release Syndrome Proteins
(76)
Format
Animal-free
(2)
Publications
No
(77)
Tag
6His, N-terminus
(3)
GST
(2)
GST, N-terminus
(1)
His
(16)
His, N-Terminal
(6)
His, N-terminus
(1)
His,C-terminus
(1)
His-GST, N-terminus
(3)
His-T7
(1)
Human IgG1 Fc
(1)
Human IgG2 Fc
(1)
Human Mutant IgG1 Fc
(1)
Mouse Mutant IgG2a Fc
(1)
Myc-DDK (Flag)
(3)
Species
Bovine
(2)
Chicken
(1)
Dog
(3)
Human
(33)
Monkey-Rhesus
(1)
Mouse
(17)
Pig
(4)
Rabbit
(2)
Rat
(8)
Rhesus monkey
(2)
Sheep
(3)
Source
293F Cells
(6)
293T Cells
(1)
CHO Cells
(5)
E. coli
(46)
HEK 293 Cells
(7)
Human
(2)
Wheat Germ Extract
(2)
Yeast
(4)
Purification
Purified
(26)
Low Endotoxin Level
Low endotoxin level
(33)
Biologically Active
Biologically active
(26)
Animal-free
Animal-free
(2)
CHO Cells
Human Mutant IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$358
Yeast
6His, N-terminus
26.4 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
CHO Cells
Human IgG1 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
50 µg/$337
E. coli
None
Biologically active
20.7 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
293F Cells
His, N-Terminal
50 µg/$790; 10 µg/$337; 200 µg/$1,416; 100 µg/$1,200; 1 mg/$2,710; 500 µg/$2,206; 5 mg/$5,524; 2 mg/$2,947
CHO Cells
His
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
24-26 kDa (SDS-PAGE)
5 µg/$278; 25 µg/$364
293F Cells
His, N-Terminal
27-33kDa
10 µg/$325; 50 µg/$720; 200 µg/$1,322; 100 µg/$1,116; 1 mg/$2,593; 500 µg/$2,090; 5 mg/$5,027; 2 mg/$2,785
293F Cells
His, N-Terminal
22/24kDa
10 µg/$313; 50 µg/$640; 200 µg/$1,210; 100 µg/$1,018; 1 mg/$2,446; 500 µg/$1,948; 5 mg/$4,467; 2 mg/$2,638
E. coli
His
24.9 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
None
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant human IL6 consists of 184 amino acids and migrates with an apparent molecular mass of 20.3 kDa as estimated in SDS-PAGE under reducing conditions.
1 mg/$2,344; 20 µg/$325; 100 µg/$570
E. coli
None
SDS-PAGE
Biologically active
The recombinant mouse IL6 consists of 188 amino acids and predicts a molecular mass of 21.9 kDa. It migrates as an approximately 22 kDa band in SDS-PAGE under reducing conditions.
20 µg/$333; 100 µg/$519; 1 mg/$2,675
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
20.8 kDa
20 µg/$1,107
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
21.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
Human
None
23.3kDa
50 µg/$690; 10 µg/$321; 200 µg/$1,281; 100 µg/$1,080; 1 mg/$2,540; 500 µg/$2,038; 5 mg/$4,817; 2 mg/$2,732
Human
None
50 µg/$662; 10 µg/$316; 200 µg/$1,242; 100 µg/$1,045; 1 mg/$2,488; 500 µg/$1,989; 5 mg/$4,621; 2 mg/$2,680
293T Cells
Myc-DDK (Flag)
23.72 kDa
20 µg/$150
HEK 293 Cells
His
22.5 kDa
10 µg/$343; 50 µg/$662; 100 µg/$992
HEK 293 Cells
His
23.3 kDa
10 µg/$348; 50 µg/$690; 100 µg/$1,026
E. coli
GST
47.8 kD
1 mg/$1,679; 100 µg/$598; 20 µg/$405
Yeast
His
22.4 kD
100 µg/$679; 20 µg/$429; 1 mg/$1,973
Wheat Germ Extract
GST
48.95 kDa
10 µg/$479; 25 µg/$670
E. coli
6His, N-terminus
23 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
21-23 kDa (SDS-PAGE)
50 µg/$355; 10 µg/$273; 1 mg/$1,576
E. coli
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
20.9 kDa (SDS-PAGE)
50 µg/$364; 10 µg/$278; 1 mg/$1,612
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